I havent been and checked all NPCs, and I doubt many have, so here is "What all NPCs should know, but may do already"
1: Trasok/harnquist (depending on Town, maybe regardless of town)
2: Where Hydlaa/Oja/Gugrontid/BD are located with general direction (maybe just have oja people direct to hydlaa then tell the player to ask when they get there if they wanted Gugrontid/BD?)
3: What/Who is Laanx/Talad.
4: Where are the sewers
5: Where is the Tavern (probably city dependant)
6: Which way is north ;o)
7: What time is it (im grasping at straws now ;op)
8: Where am I.
Maybe, and im not sure if this fits in with your plans, include some OOC info about the game? enclosed in [] of course. so:
9: how can the player get help [Use the Help tab of the chat box or ask around in game but remember to keep main chan IC] (maybe forum url and IRC info?)
I cant think of anything more, hope this helps though ;o)