As I understand, a quest wipe will mean the following:
- you can no longer count how many quests you did
- quests that you partly did, you will have to do all over again (you could try to use items you still have, but that may not always work).
But on the positive side:
- many quest conflicts are gone. I would say that it is good to only wipe after a next release, to avoid quests getting messed up again.
- you can do one time quests again (although a slight exploit possibly)
- some quests are broken, and in order to fix them, a quest reset is needed. I would suggest to fix as many of such quests before a wipe, so no single quest resets have to be done
Clearly I lean heavily to the 'yes' side, if after/at next release and hopefully fixing more quests.
Addition (there were 3 replies now):
factions, winch access (I think) and inventory are not stored in the quest history, so would not be reset. Unless winch access checks a quest pre-requisite everytime you try to enter, in which case you will have to redo the quests.