Yeah, I'm all for a quest wipe. Provided all known quest bugs are fixed and those conflict issues are resolved, this seems to be a good time to do it. Recently with an alt I did 8 bronze door quests at once and didn't have a problem..

Doing those one at a time is crazy.
I don't think wiping quest items is necessary. I certainly wouldn't want to lose some of those glyphs. It will also give us an opportunity to get other glyphs in cases where we were offered a choice, and they're not available anywhere else.

As for quest items being dropped, that is simple...just enable NPC's to buy them for a few tria. If it's not worth the trip, some newbie can profit off of picking them up. As for those in between items (ones to be given to another NPC to continue the quest) but because something happened and we are stuck with those items, it'll be nice to have them as a backup in case they are lost the second time around. After that just give them to a gm to be destroyed.
As for factions, yes, I think those should be wiped too. Are they even being used for anything yet? And here's the big question (hopefully this can be disclosed) do factions currently determine whether one can get certain quests?

If not, how close are we to that and would a quest wipe actually help with that? If it's reasonably close, I'd say wait for that to be in place.