If all that means, faction points finally become impacting: Yay! Hope people will start to ponder about to "type yes casually", when asked to accept a quest. Perhaps some chars will get ambushed by hostile npcs, others not at all.. perhaps differently expensive stuff from merchants for chars with different merchants factions, maybe some wont be able to buy from certain merchants at all (hey, perhaps some balancing, for chars may either be able to pay here or there - with whole different offers!).. perhaps some are able to "spot" spices (alchemical ingredients) in the wilds others are not.. ? Sounds grand!
Greasing..? There should definitely be some corruptive options available (like the "shady way into Winch")! Maybe not easy to access, certain faction points required, besides having to pay?
If that warning in the initial means, only quests solved in the future may become impacting: What about the already gathered faction points?
Alts for ooc reasons.. some items are paid well for on the market, like glyphs or shields. Glyphs for instance are meant to be found on random locations, growing on trees, rocks, animals etc., although rare (if I am mistaking please correct me) - mechanically though many glyphs are only available by questing, Some chars may be meant to be rich merchants with connections to others, like on other levels and whatnot - does all that mean you are only allowed to play out stuff like "doing as if"? Questing is a difficult topic anyway, just think of that one certain npc that meanwhile must have rewarded people with dozens and hundreds of shields. Realistic? Not at all, but playing a char who is meant to receive regularly loads from fabricants (or "glyph-runners", whatever) surely may be.
So after all, I say yes, I can see good reasons to do so.
Ps: So devs, how about adding very rare chances to loot glyphs from beasts and collectable plants in the wild?